Radiation is a DNA damage-based treatment modality utilized in the treatment of metastatic/aggressive Ewing sarcoma. The impact of radiation on Ewing tumor immunobiology is understudied. TGF-B is an immunosuppressive cytokine that can be upregulated during radiation therapy. Our laboratory has an ongoing project examining the utility of TGF-B inhibition on enhancing the anti-tumor immune response post-radiation in Ewing sarcoma.